A 1.6 mile stretch of the A453 will be closed tonight as work on the road continues.
The road will be shut between the East Midlands Parkway junction and the M1 between 9pm to 5am.
The closure is taking place to enable contractors to switch traffic on to another new section of carriageway as part of the multi-million pound scheme to widen the road.
Highways Agency Assistant Project Manager Robin Jackson said: "We advise road users to allow extra time for their journeys during the overnight closure and to take care and pay attention to the new road layout in the morning as there will be a significant change to get used to."
During the overnight closure through traffic will be diverted from M1 junction 24 to junction 25 and along the A52 to its junction with the A453, or vice versa.
Road users are also reminded that overnight closures of the southern bridge at M1 junction 24 continue throughout September and contractors are still on track to close that part of the junction over the weekend 19 to 22 September.
Road users are advised to allow extra time for their journeys, particularly if they have a flight to catch at East Midlands Airport.
